Overexpression of matrix metalloproteinases, chemokines, and chemokine receptors relevant for metastasis in experimental models not an indication of lymph node metastases in human melanoma.

نویسندگان

  • Kerstin Otto
  • Hans Starz
  • Juergen C Becker
  • David Schrama
چکیده

even in old age. No patient had granuloma annulare at last examination. Interesting comorbidities are listed in the Table. Most patients with conditions or diseases had only ordinary ones such as hypertension, hyperlipidemias, degenerative joint disease, and atherosclerosis. In summary, patients who develop granuloma annulare usually heal, remain remarkably healthy, and do not ordinarily develop other odd diseases.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A rare case of primary malignant melanoma of cervix with metastasis to inguinal lymph node detected on 18F-FDG PET-CT scan

Primary malignant melanoma of uterine cervix is extremely rare malignancy with very few case published reports. This neoplasm is having poor prognosis, so early diagnosis, staging and treatment is of extreme importance. 18F-FDG PET-CT (18F-labeled fluoro-2-deoxyglucose positron emission computed tomography) scan is an established modality to determine exact extent of disea...

متن کامل

Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation.

Expression of matrix metalloproteinases (MMPs) and their activation in tumor cells, as well as tumor surrounding stromal cells have been implicated in tumor cell invasion and metastasis. By means of a syngeneic tumor model for either experimental or spontaneous metastases, the differential expression of MMPs and tissue inhibitors of MMPs (TIMPs) in relation to the microenvironment and the way o...

متن کامل

Sentinel lymph node biopsy correctly predicts regional lymph node recurrence in trunk malignant melanoma with multiple drainage basins

We report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (SLN) biopsy.  Four peritumoral intradermal Tc-99m phytate injection was performed and SLNs were detected in both axillary and right inguinal regions. On the biopsy only the right axillary SLN was metastatic leading to right axilla...

متن کامل

Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma

Introduction: Metalloproteinases and their tissue inhibitors play an important role in the metastases formation. A multistage process of carcinogenesis requires the involvement of numerous enzymes and compounds that facilitate the expansion of tumor cells. The formation of metastases depends on both metalloproteinases and tissue inhibitors activation leading to the acti...

متن کامل

The role of chemokines and chemokine receptors in mycosis fungoides

Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Archives of dermatology

دوره 143 7  شماره 

صفحات  -

تاریخ انتشار 2007